Sulindac (MK-231)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25g | $450 | Check With Us |
| 50g | $650 | Check With Us |
| 100g | $980 | Check With Us |
: Cat #: V1042 CAS #: 38194-50-2 Purity ≥ 98%
Description: Sulindac (Aflodac; Algocetil; MK231; MK 231; MK-231), belonging to the arylalkanoic acid class of non-steroidal antiinflammatory drugs (NSAIDs), is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis.
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| Molecular Weight (MW) | 356.41 |
|---|---|
| Molecular Formula | C20H17FO3S |
| CAS No. | 38194-50-2 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 71 mg/mL (199.2 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 9 mg/mL (25.25 mM) | |
| Synonyms | Sulindac; Aflodac; MK231; MK 231; Algocetil; MK-231; |
| Protocol | In Vitro | Sulindac (MK-231) (500 μM, 48 hours) is effective in preventing TGF-β1-induced EMT with upregulation of the epithelial marker E-cadherin and downregulation of mesenchymal markers and transcription factors |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8058 mL | 14.0288 mL | 28.0576 mL | 56.1151 mL |
| 5mM | 0.5612 mL | 2.8058 mL | 5.6115 mL | 11.2230 mL |
| 10mM | 0.2806 mL | 1.4029 mL | 2.8058 mL | 5.6115 mL |
| 20mM | 0.1403 mL | 0.7014 mL | 1.4029 mL | 2.8058 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.