Pranoprofen (Pyranoprofen)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $920 | Check With Us |
| 10g | $1450 | Check With Us |
| 20g | $2175 | Check With Us |
: Cat #: V1056 CAS #: 52549-17-4 Purity ≥ 98%
Description: Pranoprofen (also known as Pyranoprofen), a potent and approved non-steroidal anti-inflammatory drugs (NSAIDs), is a COX inhibitor that has been used as an anti-inflammatory drug in ophthalmology.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 255.27 |
|---|---|
| Molecular Formula | C15H13NO3 |
| CAS No. | 52549-17-4 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 51 mg/mL (199.8 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 6 mg/mL (23.5 mM) | |
| SMILES Code | CC(C1=CC(CC2=CC=CN=C2O3)=C3C=C1)C(O)=O |
| Synonyms | Pyranoprofen; 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid |
| Protocol | In Vitro | Pranoprofen (5-25 µM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 µM enhances H2O2 (800 µM)-induced Dicer expression in FHC cells |
|---|---|---|
| In Vivo | Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice | |
| Animal model | DSS-induced acute colitis in C57BL/6 mice | |
| Dosages | 4 mg/kg;16 mg/kg | |
| Administration | Oral administration; 4 mg/kg/16 mg/kg; 9 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9174 mL | 19.5871 mL | 39.1742 mL | 78.3484 mL |
| 5mM | 0.7835 mL | 3.9174 mL | 7.8348 mL | 15.6697 mL |
| 10mM | 0.3917 mL | 1.9587 mL | 3.9174 mL | 7.8348 mL |
| 20mM | 0.1959 mL | 0.9794 mL | 1.9587 mL | 3.9174 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.