Ibuprofen (Advil; Motrin; Brufen)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $480 | Check With Us |
| 100g | $800 | Check With Us |
| 200g | $1200 | Check With Us |
: Cat #: V1040 CAS #: 15687-27-1 Purity ≥ 98%
Description: Ibuprofen (Dolgesic; Advil, Motrin, Nurofen, Brufen among others), a potent anti-inflammatory drug of the NSAID class, is an inhibitor of COX-1 and COX-2 enzymes with IC50s of 13 μM and 370 μM, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 206.28 |
|---|---|
| Molecular Formula | C13H18O2 |
| CAS No. | 15687-27-1 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 41 mg/mL (198.8 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 41 mg/mL (198.8 mM) | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 20 mg/mL |
| Protocol | In Vivo | Ibuprofen (300 mg/kg; p.o.; daily, for 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer |
|---|---|---|
| Animal model | Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum) | |
| Dosages | 300 mg/kg, daily for 14 days | |
| Administration | Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.8478 mL | 24.2389 mL | 48.4778 mL | 96.9556 mL |
| 5mM | 0.9696 mL | 4.8478 mL | 9.6956 mL | 19.3911 mL |
| 10mM | 0.4848 mL | 2.4239 mL | 4.8478 mL | 9.6956 mL |
| 20mM | 0.2424 mL | 1.2119 mL | 2.4239 mL | 4.8478 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.