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Mefenamic Acid (CI 473; CN-35355)

This product is for research use only, not for human use. We do not sell to patients.

Mefenamic Acid (CI 473; CN-35355)
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Size Price Stock
50g$350Check With Us
100g$550Check With Us
200mg$825Check With Us
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Cat #: V1073 CAS #: 61-68-7 Purity ≥ 98%

Description: Mefenamic Acid (CI-473; CN-35355; CI 473; CN 35355; Mefenamic Acid; Ponstel; Parkemed; Coslan), a nonsteroidal anti-inflammatory drug (NSAID), is potent, nonselective, competitive inhibitor of the enzymes COX-1 and COX-2 with anti-inflammatory activity.

References: Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

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Molecular Weight (MW)241.29
Molecular FormulaC15H15NO2
CAS No.61-68-7
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 48 mg/mL (198.9 mM)rr
Water: <1 mg/mLrr
Ethanol: <1 mg/mL
SMILES Codec1(c(cccc1)C(=O)O)Nc1c(c(ccc1)C)C
SynonymsCI-473; CN-35355; CI473; CN35355; CI 473; CN 35355; Mefenamic Acid; Ponstel; Parkemed; Coslan
ProtocolIn VitroMefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.1444 mL20.7220 mL41.4439 mL82.8878 mL
5mM0.8289 mL4.1444 mL8.2888 mL16.5776 mL
10mM0.4144 mL2.0722 mL4.1444 mL8.2888 mL
20mM0.2072 mL1.0361 mL2.0722 mL4.1444 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.