MGH-CP1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $550 | To Be Confirmed |
| 250mg | $1050 | To Be Confirmed |
| 500mg | $1575 | To Be Confirmed |
: Cat #: V48932 CAS #: 896657-58-2 Purity ≥ 99%
Description: MGH-CP1 is a novel TEAD2/4 auto-palmitoylation inhibitor with IC50 values of 710 nM and 672 nM, respectively.
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| Molecular Weight (MW) | 368.50 |
|---|---|
| Molecular Formula | C20H24N4OS |
| CAS No. | 896657-58-2 |
| SMILES Code | O=C(NC1=CC=C(C2(C[C@H]3C4)C[C@@H](C3)C[C@@H]4C2)C=C1)CSC5=NN=CN5 |
| Synonyms | MGH-CP1; MGHCP1; MGH CP1; |
| Protocol | In Vitro | MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion. MGH-CP1 does not affect YAP nuclear localization or protein levels but potently inhibits TEAD-mediated transcription in a dose-dependent manner and effectively blocks cell over-proliferation. MGH-CP1 (0-2 μM) inhibits TEAD-binding sites (TBS)-Luc reporter activity in a dose-dependent manner in YAP-expressing HEK293 cells. MGH-CP1 (0-100 μM) inhibits auto-palmitoylation of recombinant TEAD2 and TEAD4 in a dose-dependent manner. |
|---|---|---|
| In Vivo | MGH-CP1 (75mg/kg; PO; daily, for 2 weeks) inhibits the palmitoylation of TEAD proteins in the intestinal epithelium in wild-type mice, but inhibits upregulation of the TEAD target genes, CTGF and ANKRD1, in Lats1/2 KO mice intestine. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7137 mL | 13.5685 mL | 27.1370 mL | 54.2741 mL |
| 5mM | 0.5427 mL | 2.7137 mL | 5.4274 mL | 10.8548 mL |
| 10mM | 0.2714 mL | 1.3569 mL | 2.7137 mL | 5.4274 mL |
| 20mM | 0.1357 mL | 0.6784 mL | 1.3569 mL | 2.7137 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.