Darinaparsin (ZIO101; SP02)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $700 | To Be Confirmed |
| 250mg | $1350 | To Be Confirmed |
| 500mg | $2025 | To Be Confirmed |
: Cat #: V17256 CAS #: 69819-86-9 Purity ≥ 98%
Description: Darinaparsin (ZIO-101, SP-02) is a novel and potent mitochondrial-targeted small molecule and an organic arsenic that is being developed for the treatment of various hematologic and solid cancers.
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| Molecular Weight (MW) | 411.31 |
|---|---|
| Molecular Formula | C12H22AsN3O6S |
| CAS No. | 69819-86-9 |
| SMILES Code | O=C(O)[C@@H](N)CCC(N[C@@H](CS[As](C)C)C(NCC(O)=O)=O)=O |
| Synonyms | SP-02; SP 02; SP02; Darinaparsin; Zinapar; ZIO 101; ZIO101; ZIO-101 |
| Protocol | In Vitro | Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations. |
|---|---|---|
| In Vivo | Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4313 mL | 12.1563 mL | 24.3126 mL | 48.6251 mL |
| 5mM | 0.4863 mL | 2.4313 mL | 4.8625 mL | 9.7250 mL |
| 10mM | 0.2431 mL | 1.2156 mL | 2.4313 mL | 4.8625 mL |
| 20mM | 0.1216 mL | 0.6078 mL | 1.2156 mL | 2.4313 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.