Meisoindigo
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1200 | Check With Us |
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
: Cat #: V23689 CAS #: 97207-47-1 Purity ≥ 99%
Description: Meisoindigo is a novel and potent apoptosis inducer.
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- Related Biological Data
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| Molecular Weight (MW) | 276.29 |
|---|---|
| Molecular Formula | C17H12N2O2 |
| CAS No. | 97207-47-1 |
| SMILES Code | CN(C1=CC=CC=C1/C2=C3C(NC4=C\3C=CC=C4)=O)C2=O |
| Synonyms | N-Methylisoindigotin; Meisoindigo; Dian III; Methyl isoindigotin; |
| Protocol | In Vitro | Meisoindigo (5-10 μM; for 24 hours) increases the cleaved caspase-3 and pro-apoptotic Bak, and decreases Bcl-2 and Bcl-xL levels in HL-60 cells. Meisoindigo (5-10 μM; for 24 hours) causes cell-cycle arrest. Meisoindigo (10 μM; for 24 hours) induces apoptosis of acute myeloid leukemia. Meisoindigo (Dian III; 5-20 μM; for 24 hours) inhibits growth of the AML cell lines. |
|---|---|---|
| In Vivo | Meisoindigo (Dian III; 50-150 mg/kg; IP; daily; for 14 days) has anti-leukemic activity in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6194 mL | 18.0969 mL | 36.1939 mL | 72.3877 mL |
| 5mM | 0.7239 mL | 3.6194 mL | 7.2388 mL | 14.4775 mL |
| 10mM | 0.3619 mL | 1.8097 mL | 3.6194 mL | 7.2388 mL |
| 20mM | 0.1810 mL | 0.9048 mL | 1.8097 mL | 3.6194 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.