FB23-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | In Stock |
| 500mg | $2250 | In Stock |
| 1g | $3375 | In Stock |
: Cat #: V31465 CAS #: 2243736-45-8 Purity ≥ 98%
Description: FB23-2 (FB23-2; FB-23-2; FB 232) is a novel, potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 392.24 |
|---|---|
| Molecular Formula | C18H15Cl2N3O3 |
| CAS No. | 2243736-45-8 |
| SMILES Code | O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl |
| Synonyms | FB232; FB-232; FB 232; FB23-2; FB-23-2; FB 23-2; |
| Protocol | In Vitro | FB23-2 induces apoptosis (1-20 μM; 48-72 hours) and cell cycle arrest (5-20 μM; 24 hours) at G1 stage in AML cells. FB23-2 (1-20 μM; 72 hours) significantly increases the mRNA and protein levels of ASB2 and RARA in NB4 and MONOMAC6 cells. FB23-2 exhibits FTO-dependent anti-proliferation activity and promotes myeloid differentiation and apoptosis. FB23-2 (0.5-5 μM; 24-72 hours) significantly suppresses the proliferation of BM cells from these two models in a dose-dependent manner. FB23-2 (20 μM; 72 hours) displays anti-proliferation effect via upregulating global m6A levels. FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC50 values of 0.8 μM and 1.5 μM. FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human AML cell line cells and primary blast AML cells. |
|---|---|---|
| In Vivo | FB23-2 exhibits elimination half-life (rat 6.7 h) and Cmax (rat 2421.3 ng/mL) following intraperitoneal injection (rat 3 mg/kg). FB23-2 (2 mg/kg; i.p.; daily; for 10 days) substantially suppresses leukemia progression and prolongs survival. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5495 mL | 12.7473 mL | 25.4946 mL | 50.9892 mL |
| 5mM | 0.5099 mL | 2.5495 mL | 5.0989 mL | 10.1978 mL |
| 10mM | 0.2549 mL | 1.2747 mL | 2.5495 mL | 5.0989 mL |
| 20mM | 0.1275 mL | 0.6374 mL | 1.2747 mL | 2.5495 mL |
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Method for preparing in vivo formulation:
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Tween 80,mix and clarify, next add
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ddH2O,mix and clarify.
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