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Gemcitabine monophosphate disodium

This product is for research use only, not for human use. We do not sell to patients.

Gemcitabine monophosphate disodium
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1450To Be Confirmed
500mg$2080To Be Confirmed
1g$3120To Be Confirmed
email: [email protected]        [email protected]

Cat #: V4888 CAS #: 1638288-31-9 Purity ≥ 98%

Description: Gemcitabine monophosphate disodium (GemMP) is a monophosphate analog of Gemcitabine (formerly also known as LY-188011, NSC 613327; dFdC; dFdCyd; gemcitabine; trade name: Gemzar), an antimetabolite anticancer drug, which is a potent DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

References: Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611.

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Molecular Weight (MW)387.14
Molecular FormulaC9H10F2N3Na2O7P
CAS No.1638288-31-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C1N=C(N)C=CN1[C@@H]2O[C@H](COP(O[Na])(O[Na])=O)[C@@H](O)C2(F)F.O
SynonymsGemcitabine monophosphate disodium; GemMP; Gemcitabine monophosphate disodium salt monohydrate;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5830 mL12.9152 mL25.8304 mL51.6609 mL
5mM0.5166 mL2.5830 mL5.1661 mL10.3322 mL
10mM0.2583 mL1.2915 mL2.5830 mL5.1661 mL
20mM0.1292 mL0.6458 mL1.2915 mL2.5830 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.