Aromadedrin (Dihydrokaempferol)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $850 | Check With Us |
| 200mg | $1275 | Check With Us |
| 500mg | $2150 | Check With Us |
: Cat #: V8035 CAS #: 480-20-6 Purity ≥ 99%
Description: Aromadedrin, isolated from Bauhinia championii (Benth), also known as Dihydrokaempferol, is a novel and potent inhibitor of protein kinase C. Dihydrokaempferol in an inducer of apoptosis and is an inhibitor of Bcl-2 and Bcl-xL expression.
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| Molecular Weight (MW) | 288.25 |
|---|---|
| Molecular Formula | C15H12O6 |
| CAS No. | 480-20-6 |
| SMILES Code | O=C1[C@H](O)[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13 |
| Synonyms | (+) Dihydrokaempferol; Dihydrokaempferol; trans-Dihydrokaempferol; trans Dihydrokaempferol; Aromadendrin; (+)-Aromadendrin; (+) Aromadendrin; |
| Protocol | In Vitro | Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively). Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4692 mL | 17.3461 mL | 34.6921 mL | 69.3842 mL |
| 5mM | 0.6938 mL | 3.4692 mL | 6.9384 mL | 13.8768 mL |
| 10mM | 0.3469 mL | 1.7346 mL | 3.4692 mL | 6.9384 mL |
| 20mM | 0.1735 mL | 0.8673 mL | 1.7346 mL | 3.4692 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.