T-1101 tosylate (TAI-95 tosylate)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2250 | Check With Us |
| 200mg | $3375 | Check With Us |
| 500mg | $5695 | Check With Us |
: Cat #: V34669 CAS #: 2250404-95-4 Purity ≥ 99%
Description: T-1101 tosylate (also known as TAI95 tosylate) is a potent inhibitor of Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 665.80 |
|---|---|
| Molecular Formula | C31H31N5O6S3 |
| CAS No. | 2250404-95-4 |
| SMILES Code | CC1=CC(SC2=NC=C(OCCOC)N=C2)=CC(C)=C1C3=CSC(NC(C4=CC=NC=C4)=O)=N3.CC(C=C5)=CC=C5S(=O)(O)=O |
| Synonyms | TAI-95 tosylate; TAI95 tosylate; TAI 95 tosylate; T-1101 tosylate; T1101 tosylate; T 1101 tosylate; |
| Protocol | In Vitro | T-1101 tosylate reduces amounts of cell-cycle related proteins cyclin A1, cyclin B1, and cyclin D1. T-1101 tosylate (1 µM; 24 hours) induces apoptosis. T-1101 tosylate (1μM; 3-24 24 hours) decreases the level of Nek2 in a time-dependent manner. T-1101 tosylate disrupts the Hec1/Nek2 protein–protein interaction in the cells. T-1101 tosylate shows potent in vitro antiproliferative activity (IC50: 14.8-21.5 nM). |
|---|---|---|
| In Vivo | T-1101 tosylate (2.5 mg/kg; p.o.; twice per day) shows significant in vivo activity in mice bearing various human cancer xenografts. Oral co-administration of T-1101 tosylate (2.5 mg/kg; p.o.; twice per day) halves the dose of sorafenib (25 mg/kg to 12.5 mg/kg) required to exhibit comparable in vivo activity towards Huh-7 xenografts . T-1101 tosylate shows good oral bioavailability and thermal stability. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5020 mL | 7.5098 mL | 15.0195 mL | 30.0391 mL |
| 5mM | 0.3004 mL | 1.5020 mL | 3.0039 mL | 6.0078 mL |
| 10mM | 0.1502 mL | 0.7510 mL | 1.5020 mL | 3.0039 mL |
| 20mM | 0.0751 mL | 0.3755 mL | 0.7510 mL | 1.5020 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.