CCI 007
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1700 | Check With Us |
| 250mg | $2950 | Check With Us |
| 500mg | $4425 | Check With Us |
: Cat #: V2443 CAS #: 939228-52-1 Purity ≥ 99%
Description: CCI-007 is a potent and selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.
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| Molecular Weight (MW) | 336.36 |
|---|---|
| Molecular Formula | C15H16N2O5S |
| CAS No. | 939228-52-1 |
| Synonyms | CCI-007 |
| Protocol | In Vitro | Resistance to CCI-007 can occur by upregulation of MLL target gene expression. Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2. CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9730 mL | 14.8650 mL | 29.7301 mL | 59.4601 mL |
| 5mM | 0.5946 mL | 2.9730 mL | 5.9460 mL | 11.8920 mL |
| 10mM | 0.2973 mL | 1.4865 mL | 2.9730 mL | 5.9460 mL |
| 20mM | 0.1487 mL | 0.7433 mL | 1.4865 mL | 2.9730 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.