Azoramide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V3175 CAS #: 932986-18-0 Purity ≥ 98%
Description: Azoramide is a small-molecule modulator of the unfolded protein response (UPR) and an ER stress alleviator that is reported to have antidiabetic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 308.83 |
|---|---|
| Molecular Formula | C15H17ClN2OS |
| CAS No. | 932986-18-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >61 mg/mL (197.5 mM)r |
| Water: < 1 mg/mLr | |
| Ethanol: >61 mg/mL (197.5 mM) | |
| SMILES Code | CCCC(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)=O |
| Synonyms | Azoramide |
| Protocol | In Vitro | Azoramide (15 µM; 2-16 h; Huh7 cells) protects cells from induced ER stress. Azoramide counteracts Tunicamycin (Tm, HY-A0098)-induced ATF6LD-Cluc secretion and Tm-induced decrease of ASGR-Cluc secretion. Azoramide suppresses Tm-induced GRP78 and CHOP protein expression. Azoramide (0.01-100 µM; 0-24 h; Huh7 cells) regulates ER folding and secretion capacity without inducing ER stress. Azoramide (15 µM; 2-16 h; Hepa 1-6 cells) alters ER calcium homeostasis and retains a greater fraction of Ca2+ in the ER. |
|---|---|---|
| In Vivo | Azoramide (150 mg/kg; p.o.; daily, for 7 d; Huh7 cells; ob/ob mice) improves glucose homeostasis in mice with genetic obesity and preserves beta cell function and survival during metabolic ER stress. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2380 mL | 16.1901 mL | 32.3803 mL | 64.7605 mL |
| 5mM | 0.6476 mL | 3.2380 mL | 6.4761 mL | 12.9521 mL |
| 10mM | 0.3238 mL | 1.6190 mL | 3.2380 mL | 6.4761 mL |
| 20mM | 0.1619 mL | 0.8095 mL | 1.6190 mL | 3.2380 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.