Embelin | CAS 550-24-3

Embelin

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$460	Check With Us
500mg	$750	Check With Us
1g	$1125	Check With Us

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Cat #: V0054 CAS #: 550-24-3 Purity ≥ 98%

Description: Embelin is a naturally occuring quinone compound isolated from the Japanese Ardisia herb with anti-tumor and anti-inflammatory activity, acting as a potent and cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) with IC50 of 4.1 μM in cell-free assays.

References: Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47(10):

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	294.39
Molecular Formula	C17H26O4
CAS No.	550-24-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 59 mg/mL (200.41 mM)r
	Water: <1 mg/mL (slightly soluble or insoluble)r
	Ethanol: 12 mg/mL (40.76 mM)
SMILES Code	O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Synonyms	Embelin; Emberine; Embelic acid; NSC91874; NSC91874; NSC 91874;

Protocol	In Vitro	Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3969 mL	16.9843 mL	33.9685 mL	67.9371 mL
5mM	0.6794 mL	3.3969 mL	6.7937 mL	13.5874 mL
10mM	0.3397 mL	1.6984 mL	3.3969 mL	6.7937 mL
20mM	0.1698 mL	0.8492 mL	1.6984 mL	3.3969 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.