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Thalidomide (Immunoprin, Contergan and Thalomid)

This product is for research use only, not for human use. We do not sell to patients.

Thalidomide (Immunoprin, Contergan and Thalomid)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5g$250In Stock
10g$400In Stock
20g$600In Stock

Cat #: V0036 CAS #: 50-35-1 Purity ≥ 98%

Description: Thalidomide (trade names Immunoprin, Contergan and Thalomid among others) is a potent immunomodulatory agent and a drug approved in the 1950s.

References: Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.

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Promise
Molecular Weight (MW)258.23
Molecular FormulaC13H10N2O4
CAS No.50-35-1
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 52 mg/mL (201.37 mM)r
Water:<1 mg/mL (slightly soluble or insoluble)r
Ethanol: 2 mg/mL (7.74 mM)
Solubility In Vivo30% PEG400+0.5% Tween80+5% Propylene glycol: 5 mg/mL
SMILES CodeO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
SynonymsBrand names: Synovir; Thalomid (US); Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide.
ProtocolIn VitroThalidomide has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties, and targets cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM.
In VivoThalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.8725 mL19.3626 mL38.7252 mL77.4503 mL
5mM0.7745 mL3.8725 mL7.7450 mL15.4901 mL
10mM0.3873 mL1.9363 mL3.8725 mL7.7450 mL
20mM0.1936 mL0.9681 mL1.9363 mL3.8725 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.