R-7050 | CAS 303997-35-5

R-7050

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1050	Check With Us
500mg	$1650	Check With Us
1g	$2475	Check With Us

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Cat #: V13563 CAS #: 303997-35-5 Purity ≥ 98%

Description: R-7050 (R7050) is a novel, potent and selective tumor necrosis factor/ TNF-α receptor antagonist acting by blocking receptor-adaptor molecule complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding.

References: Gururaja TL, et al. A class of small molecules that inhibit TNFalpha-induced survival and death pathways viaprevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol. 2007 Oct;14(10):1105-18.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	380.77
Molecular Formula	C16H8ClF3N4S
CAS No.	303997-35-5
SMILES Code	FC(C1=NN=C2N1C3=C(C=CC(Cl)=C3)N=C2SC4=CC=CC=C4)(F)F
Synonyms	TNF-α Antagonist III; R-7050; R 7050; R7050;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6263 mL	13.1313 mL	26.2626 mL	52.5251 mL
5mM	0.5253 mL	2.6263 mL	5.2525 mL	10.5050 mL
10mM	0.2626 mL	1.3131 mL	2.6263 mL	5.2525 mL
20mM	0.1313 mL	0.6566 mL	1.3131 mL	2.6263 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.