Tenovin-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $739 | Check With Us |
| 1g | $1150 | Check With Us |
| 5g | $2900 | Check With Us |
: Cat #: V0016 CAS #: 380315-80-0 Purity ≥ 98%
Description: Tenovin-1, a small molecule compound discovered by a cell-based screen, is a novel and potent activator of p53 that protects against MDM2-mediated p53 degradation.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 369.48 |
|---|---|
| Molecular Formula | C20H23N3O2S |
| CAS No. | 380315-80-0 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 74 mg/mL (200.28 mM)rr |
| Water:<1 mg/mL (slightly soluble or insoluble)rr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 15% Captisol: 15 mg/mL |
| SMILES Code | O=C(NC(NC1=CC=C(NC(C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2 |
| Synonyms | Tenovin-1; Tenovin1; Tenovin 1 |
| Protocol | In Vitro | Tenovin-1 protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 targets a factor(s) upstream of p53 that not only modulates p53 function but also other cellular pathways. Tenovin-1 (10 μM) inhibits SirT2 deacetylase activity. |
|---|---|---|
| In Vivo | Tenovin-1 (92 mg/kg, i.p.) reduces growth of tumors in SCID mice derived from BL2 cells or ARN8 cells. | |
| Animal model | Female SCID mice injected subcutaneously with ARN8 cells suspended in matrigel. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Related Biological Data |
|
|---|
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7065 mL | 13.5325 mL | 27.0651 mL | 54.1301 mL |
| 5mM | 0.5413 mL | 2.7065 mL | 5.4130 mL | 10.8260 mL |
| 10mM | 0.2707 mL | 1.3533 mL | 2.7065 mL | 5.4130 mL |
| 20mM | 0.1353 mL | 0.6766 mL | 1.3533 mL | 2.7065 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.