Tenovin-1, a small molecule compound discovered by a cell-based screen, is a novel and potent activator of p53 that protects against MDM2-mediated p53 degradation.

COTI-2 is an orally available, 3rd generation small molecule activator of the mutant p53 protein (a tumor suppressor).

NSC 146109 (NSC-146109) HCl, the hydrochloride salt of NSC-146109, is a novel and potent small-molecule p53 activator that targets MDMX, it has the potential in treating breast cancer.

Tenovin-3 is a small molecule activator of p53 transcriptional activity and an inhibitor of sirtuin.

Pifithrin-β HBr (QB-102; Cyclic-Pifithrin-α), the hydrobromide salt of Pifithrin-β, is a potent p53 inhibitor (IC50 of 23 μM) and a cell-permeable Cyclized analog of Pifithrin-α with higher stability and reduced cytotoxicity.

NSC319726 is a novel and potent p53(R175) mutant reactivator with with potential anticancer activity.

Pifithrin-α HBr ((PFTα hydrobromide; PFT-α) is a novel and potent inhibitor of p53, acting by inhibiting p53 protein transcription and p53-dependent transactivation of p53-responsive genes.

Tenovin-6 is an analog of tenovin-1 with more water-soluble and it inhibits the protein deacetylase activities of SIRT1, SIRT2 and SIRT3 with IC50 value of 21 μM, 10 μM, and 67 μM, respectively.

Pifithrin-μ (NSC303580) is a novel and potent inhibitor of p53 binding and p53-mediated apoptosis with a Kd of 0.82 mM in vitro.

MS7972 is a novel and potent CREBBP inhibitor.