740 Y-P (PDGFR 740Y-P)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$2250	Check With Us
200mg	$3375	Check With Us
500mg	$5695	Check With Us

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Cat #: V2540 CAS #: 1236188-16-1 Purity ≥ 98%

Description: 740 Y-P is a cell-permeable peptide acting as a phosphopeptide activator of PI3K. 740 Y-P plays an important role in PI3K/AKT signaling pathway.

References: Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	3270.70
Molecular Formula	C141H222N43O39PS3
CAS No.	1236188-16-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: N/Ar
	Water: 20 mg/mLr
	Ethanol: N/A
Synonyms	740 YPDGFR; PDGFR 740Y-P; 740 Y-P; 740 YP; 740YPDGFR; PDGFR740Y-P; 740 Y P; 740-YPDGFR; PDGFR 740 Y-P;

Protocol	In Vitro	740 Y-P (1 μg/mL) stimulates mitogenesis at the lowest concentration tested. The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 μg/mL. 740Y-P to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides. 740 Y-P (50 μg/mL; 48 hours) specificly stimulates mitogenesis in medium is better than EGF or FGF at stimulating entry into S-phase, it shows the percentage of cells in S-phase for 48.3% in C2 cells. Additionally, LY294002 (HY-10108) or Wortmannin (HY-10197) potently inhibits the mitogenic response stimulated by the peptide.
Protocol	In Vivo	740 Y-P is not only internalised in living cells but can also interact with p85 in vivo.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.3057 mL	1.5287 mL	3.0574 mL	6.1149 mL
5mM	0.0611 mL	0.3057 mL	0.6115 mL	1.2230 mL
10mM	0.0306 mL	0.1529 mL	0.3057 mL	0.6115 mL
20mM	0.0153 mL	0.0764 mL	0.1529 mL	0.3057 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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