5-(N,N-Hexamethylene)-amiloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1250 | To Be Confirmed |
| 1g | $1950 | To Be Confirmed |
| 5g | $5265 | To Be Confirmed |
: Cat #: V32884 CAS #: 1428-95-1 Purity ≥ 99%
Description: 5-(N,N)-Dimethylamiloride Hydrochloride (Hexamethylene amiloride), an amiloride derivative, is a Na(+)-H+ exchange inhibitor that decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells.
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| Molecular Weight (MW) | 311.77 |
|---|---|
| Molecular Formula | C₁₂H₁₈ClN₇O |
| CAS No. | 1428-95-1 |
| Synonyms | Hexamethylene amiloride; HMA |
| Protocol | In Vitro | 5-(N,N-Hexamethylene)-amiloride inhibits human cardiac ion channels hERG (in CHO cells), Nav1.5 and Cav1.2 (in EHK293 cells) with of 3.3 μM, 30 μM, 8.3 μM, respectively, inelectrophysiology assays |
|---|---|---|
| In Vivo | 5-(N,N-Hexamethylene)-amiloride (2.5 mg/kg; i.v.; single dose) shows short half-life and lowly oral bioavailability of 4.5% |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2075 mL | 16.0375 mL | 32.0749 mL | 64.1499 mL |
| 5mM | 0.6415 mL | 3.2075 mL | 6.4150 mL | 12.8300 mL |
| 10mM | 0.3207 mL | 1.6037 mL | 3.2075 mL | 6.4150 mL |
| 20mM | 0.1604 mL | 0.8019 mL | 1.6037 mL | 3.2075 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.