5-Iodo-indirubin-3'-monoxime | CAS 331467-03-9

5-Iodo-indirubin-3′-monoxime

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1mg	$140	To Be Confirmed
5mg	$320	To Be Confirmed
10mg	$500	To Be Confirmed

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Cat #: V30882 CAS #: 331467-03-9 Purity ≥ 99%

Description: 5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25 and CDK1/cyclin B. It competes with ATP to bind to the catalytic site of the enzyme, with IC50s of 9, 20 and 20 respectively. 25 nM.

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Molecular Weight (MW)	403.1735
Molecular Formula	C16H10N3O2I
CAS No.	331467-03-9
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4803 mL	12.4016 mL	24.8032 mL	49.6064 mL
5mM	0.4961 mL	2.4803 mL	4.9606 mL	9.9213 mL
10mM	0.2480 mL	1.2402 mL	2.4803 mL	4.9606 mL
20mM	0.1240 mL	0.6201 mL	1.2402 mL	2.4803 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.