4-Octyl Itaconate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$512	Check With Us
2g	$820	Check With Us
5g	$1380	Check With Us

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Cat #: V30953 CAS #: 3133-16-2 Purity ≥ 98%

Description: 4-Octyl Itaconate is a novel, potent and cell-permeable analog of itaconate, which is an emerging determinant of inflammation in activated macrophages and an anti-inflammatory metabolite that can activate Nrf2 (an anti-inflammatory transcription factorvia alkylation of KEAP1.

References: Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	242.31
Molecular Formula	C13H22O4
CAS No.	3133-16-2
SMILES Code	O=C(O)C(CC(OCCCCCCCC)=O)=C
Synonyms	4-Octyl Itaconate; 4 Octyl Itaconate; 4-Octyl-Itaconate

Protocol	In Vitro	4-Octyl Itaconate (OI) is a cell-permeable itaconate derivative. 4-Octyl Itaconate is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.1269 mL	20.6347 mL	41.2694 mL	82.5389 mL
5mM	0.8254 mL	4.1269 mL	8.2539 mL	16.5078 mL
10mM	0.4127 mL	2.0635 mL	4.1269 mL	8.2539 mL
20mM	0.2063 mL	1.0317 mL	2.0635 mL	4.1269 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.