4′-Hydroxydiclofenac
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3645 | To Be Confirmed |
| 200mg | $5465 | To Be Confirmed |
| 500mg | $9220 | To Be Confirmed |
: Cat #: V9099 CAS #: 64118-84-9 Purity ≥ 99%
Description: 4'-Hydroxydiclofenac is an active CYP2C9-mediated metabolite of diclofenac which is potent nonsteroidal anti-inflammatory drug (NSAID) and a Cox-2 inhibitor.
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| Molecular Weight (MW) | 312.15 |
|---|---|
| Molecular Formula | C14H11Cl2NO3 |
| CAS No. | 64118-84-9 |
| SMILES Code | O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=C(O)C=C2Cl |
| Synonyms | 4'-Hydroxydiclofenac |
| Protocol | In Vivo | A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t1/2) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2036 mL | 16.0179 mL | 32.0359 mL | 64.0718 mL |
| 5mM | 0.6407 mL | 3.2036 mL | 6.4072 mL | 12.8144 mL |
| 10mM | 0.3204 mL | 1.6018 mL | 3.2036 mL | 6.4072 mL |
| 20mM | 0.1602 mL | 0.8009 mL | 1.6018 mL | 3.2036 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.