2R,4R-Sacubitril

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2mg	$460	3-6 Days
5mg	$760	3-6 Days
10mg	$1220	3-6 Days
25mg	$2010	3-6 Days
50mg	$3050	3-6 Days

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Cat #: V29383 CAS #: 766480-48-2 Purity ≥ 99%

Description: 2R,4R-Sacubitril is an impurity of Sacubitril (AHU377), which is an FDA approved medication acting as a NEP (neutral endopeptidase 24.11) inhibitor and used as a component of the heart failure medicine LCZ696.

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Stock Solution Preparation
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Molecular Weight (MW)	411.490767240524
Molecular Formula	C24H29NO5
CAS No.	766480-48-2
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Synonyms	2R,4R-Sacubitril; 766480-48-2; LCZ 696 Impurity B; (2R,4R)-Sacubitril; 4-((Rel-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; 4-[[(2R,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid; (R,R)-?-[(3-Carboxy-1-oxopropyl)amino]-a-methyl-[1,1'-biphenyl]-4-pentanoic Acid a-Ethyl Ester; (aR,?R)-rel-?-[(3-Carboxy-1-oxopropyl)amino]-a-methyl-[1,1'-biphenyl]-4-pentanoic Acid 4-Ethyl Ester; Sacubitril-(2R,4R) Isomer;Impurity B; SCHEMBL18574632;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4302 mL	12.1509 mL	24.3019 mL	48.6038 mL
5mM	0.4860 mL	2.4302 mL	4.8604 mL	9.7208 mL
10mM	0.2430 mL	1.2151 mL	2.4302 mL	4.8604 mL
20mM	0.1215 mL	0.6075 mL	1.2151 mL	2.4302 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.