2R,4R-Sacubitril
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $3075 | To Be Confirmed |
| 200mg | $4610 | To Be Confirmed |
| 500mg | $7780 | To Be Confirmed |
: Cat #: V29383 CAS #: 766480-48-2 Purity ≥ 99%
Description: 2R,4R-Sacubitril is an impurity of Sacubitril (AHU377), which is an FDA approved medication acting as a NEP (neutral endopeptidase 24.11) inhibitor and used as a component of the heart failure medicine LCZ696.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 411.49 |
|---|---|
| Molecular Formula | C24H29NO5 |
| CAS No. | 766480-48-2 |
| Synonyms | 2R,4R-Sacubitril |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4302 mL | 12.1510 mL | 24.3019 mL | 48.6039 mL |
| 5mM | 0.4860 mL | 2.4302 mL | 4.8604 mL | 9.7208 mL |
| 10mM | 0.2430 mL | 1.2151 mL | 2.4302 mL | 4.8604 mL |
| 20mM | 0.1215 mL | 0.6075 mL | 1.2151 mL | 2.4302 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.