2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $250 | Check With Us |
| 2g | $400 | Check With Us |
| 5g | $660 | Check With Us |
: Cat #: V0294 CAS #: 362-07-2 Purity ≥ 98%
Description: 2-Methoxyestradiol (2-MeOE2, NSC-659853, 2-ME2; 2-ME), an endogenous/natural metabolite of estradiol [17β-estradiol (E2)], is a potent inhibitor of tubulin with potential anticancer activity.
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| Molecular Weight (MW) | 302.41 |
|---|---|
| Molecular Formula | C19H26Or3 |
| CAS No. | 362-07-2 |
| Protocol | In Vitro | 2-Methoxyestradiol (2-ME) (5-100 μM) inhibits the assembly of purified tubulin in a concentration-dependent manner, with a maximum (200%) inhibition at 2 μM of 2-Methoxyestradiol (2ME60). In live interphase MCF7 cells, mitotic arrest ICs50 (1.2 μM), 2-Methoxyestradiol significantly inhibits mean microtubule growth rate, duration and length, and overall dynamics, consistent with its role in vitro, and without any observable microtubule depolymerization. 2-Methoxyestradiol induces G in many cell types that divide actively2-M arrest and apoptosis while protecting quiescent cells. 2-Methoxyestradiol binds to tubulin at or near colchicine sites, inhibits microtubule assembly, and high concentrations have been shown to depolymerize microtubules in cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3068 mL | 16.5338 mL | 33.0677 mL | 66.1354 mL |
| 5mM | 0.6614 mL | 3.3068 mL | 6.6135 mL | 13.2271 mL |
| 10mM | 0.3307 mL | 1.6534 mL | 3.3068 mL | 6.6135 mL |
| 20mM | 0.1653 mL | 0.8267 mL | 1.6534 mL | 3.3068 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.