2-DG
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $110 | Check With Us |
| 10g | $180 | Check With Us |
| 20g | $270 | Check With Us |
: Cat #: V9371 CAS #: 154-17-6 Purity ≥ 98%
Description: 2-DG (2-Deoxy-D-arabinohexose) is a potnet inhibitor of glycolysis via its actions on hexokinase, the rate limiting step of glycolysis.
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| Molecular Weight (MW) | 164.16 |
|---|---|
| Molecular Formula | C6H12O5 |
| CAS No. | 154-17-6 |
| SMILES Code | O=CC[C@H]([C@@H]([C@@H](CO)O)O)O |
| Protocol | In Vitro | 2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces ATP levels in MCF-7 cells in a dose- and time-dependent manner, similar to how 2-DG grows on cells. Upon exposure to 4, 8, or 16 mM 2-Deoxy-D-glucose 1, 3, or in a dose- and time-dependent manner for 5 days |
|---|---|---|
| In Vivo | 2-Deoxy-D-glucose (0.03%, w/w) resulted in a 7% final weight loss, which was statistically significant and delayed the emergence of palpable breast cancer |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 6.0916 mL | 30.4581 mL | 60.9162 mL | 121.8324 mL |
| 5mM | 1.2183 mL | 6.0916 mL | 12.1832 mL | 24.3665 mL |
| 10mM | 0.6092 mL | 3.0458 mL | 6.0916 mL | 12.1832 mL |
| 20mM | 0.3046 mL | 1.5229 mL | 3.0458 mL | 6.0916 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.