(1S,3R,5R)-PIM447 dihydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1880 | Check With Us |
| 250mg | $3180 | Check With Us |
| 500mg | $4770 | Check With Us |
: Cat #: V2738 CAS #: N/A Purity ≥ 98%
Description: (1S,3R,5R)-PIM447 dihydrochloride a potent PIM inhibitor extracted with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.
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| Molecular Weight (MW) | 513.39 |
|---|---|
| Molecular Formula | C24H25Cl2F3N4O |
| CAS No. | N/A |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 88 mg/mL (184.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 88 mg/mL (184.5 mM) | |
| SMILES Code | O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@H]4C[C@@H](N)C[C@@H](C)C4)C=CN=C3.[H]Cl.[H]Cl |
| Synonyms | (1S,3R,5R)-PIM447 dihydrochloride; (1S,3R,5R)-PIM-447; (1S,3R,5R)-PIM 447; (1S,3R,5R)-LGH-447 dihydrochloride; (1S,3R,5R)-LGH 447; (1S,3R,5R)-LGH447 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9478 mL | 9.7392 mL | 19.4784 mL | 38.9567 mL |
| 5mM | 0.3896 mL | 1.9478 mL | 3.8957 mL | 7.7913 mL |
| 10mM | 0.1948 mL | 0.9739 mL | 1.9478 mL | 3.8957 mL |
| 20mM | 0.0974 mL | 0.4870 mL | 0.9739 mL | 1.9478 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.