This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 10mg | $170 | 3-6 Days |
| 25mg | $290 | 3-6 Days |
| 50mg | $500 | 3-6 Days |
| 100mg | $680 | 3-6 Days |
| 250mg | $1170 | 3-6 Days |
| 500mg | $1790 | 3-6 Days |
: Cat #: V7667 CAS #: 1204918-72-8 Purity ≥ 99%
Description: Zotiraciclib (formerly TG02, SB1317) is an orally bioavailable, brain penetrant and multi-kinase (CDK/JAK2/FLT3) inhibitor for the treatment of cancer (e.g. anaplastic astrocytoma and GBM, as well as DIPG, a rare pediatric cance). In Singapore, S*BIO Pte Ltd made the discovery of this small molecule macrocyclic compound. By inhibiting cyclin-dependent kinase 9 (CDK9), it depletes Myc and passes through the blood-brain barrier (BBB). It is one of several CDK inhibitors being studied for the treatment of cancer; other CDK inhibitors that target CDK9 for the treatment of acute myeloid leukemia (AML) include atuveciclib and alvocidib. Eighty percent of glioblastomas exhibit this feature, which is indicative of myc overexpression, a factor known to be involved in a variety of cancers. The US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have designated zotiraciclib as an orphan drug for the treatment of gliomas.
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| Molecular Weight (MW) | 372.462864875793 |
|---|---|
| Molecular Formula | C23H24N4O |
| CAS No. | 1204918-72-8 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | SB1317; Zotiraciclib; TG02 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6848 mL | 13.4242 mL | 26.8483 mL | 53.6966 mL |
| 5mM | 0.5370 mL | 2.6848 mL | 5.3697 mL | 10.7393 mL |
| 10mM | 0.2685 mL | 1.3424 mL | 2.6848 mL | 5.3697 mL |
| 20mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 2.6848 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.