Zotarolimus (ABT578; A-179578)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1050	Check With Us
250mg	$1950	Check With Us
500mg	$2925	Check With Us

: [email protected] [email protected]

Cat #: V0208 CAS #: 221877-54-9 Purity ≥ 98%

Description: Zotarolimus (also known as ABT-578; A 179578), a tetrazole-based and semi-synthetic analog of rapamycin, is a highly potent immunosuppressant with the potential to be used for preventing coronary artery restenosis.

References: Sandra E Burke, et al. Zotarolimus (ABT-578) eluting stents. Adv Drug Deliv Rev. 2006 Jun 3;58(3):437-46.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	966.21
Molecular Formula	C52H79N5O12
CAS No.	221877-54-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (103.5 mM)r
	Water: <1 mg/mLr
	Ethanol: 100 mg/mL (103.5 mM)
SMILES Code	O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)CC[C@@](O2)([H])C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H]3C)=O)=O)=O)O[C@H]([C@H](C)C[C@H]4C[C@@H](OC)[C@@H](N5N=NN=C5)CC4)CC3=O
Synonyms	A179578; ABT578; ABT-578; A-179578; A 179578; ABT 578; Zotarolimus; Endeavor; Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.0350 mL	5.1749 mL	10.3497 mL	20.6994 mL
5mM	0.2070 mL	1.0350 mL	2.0699 mL	4.1399 mL
10mM	0.1035 mL	0.5175 mL	1.0350 mL	2.0699 mL
20mM	0.0517 mL	0.2587 mL	0.5175 mL	1.0350 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.