Zosuquidar (RS 33295-198; LY335979) 3HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$710	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V1294 CAS #: 167465-36-3 Purity ≥ 98%

Description: Zosuquidar 3HCl (formerly D-06387; D06387; RS33295198; LY335979; LY-335979; RS-33295198), the trihydrochloride salt of zosuquidar, is a novel and potent inhibitor P-glycoprotein (P-gp) and modulator of P-gp-mediated multi-drug resistance with potential antitumor activity.

References: A H Dantzig, et al. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 1996 Sep 15;56(18):4171-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	636.99
Molecular Formula	C32H31F2N3O2.3HCl
CAS No.	167465-36-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (157 mM)r
	Water: 23 mg/mL (36.1 mM)r
	Ethanol:<1 mg/mL
Solubility In Vivo	30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
Synonyms	RS 33295-198 (D06387) 3HCl; LY335979; D-06387; D 06387; RS33295198; LY 335979; LY-335979; RS 33295198; Zosuquidar HCl; Zosuquidar 3HCl; Zosuquidar trihydrochloride

Protocol	In Vitro	Zosuquidar (5-16 μM; 72 h) treatment alone shows high cytotoxic concentration to drug-sensitive and MDR cell lines
	In Vivo	Zosuquidar (intraperitoneal injection; 30 mg/kg; once daily; 5 d) treatment shows the potentiation with a combined of Doxorubicin
	Animal model	Mice implanted with P388/ADR tumors
	Dosages	30, 10, 3, or 1 mg/kg
	Administration	Intraperitoneal injection; 30, 10, 3, or 1 mg/kg; once daily; 5 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5699 mL	7.8494 mL	15.6988 mL	31.3977 mL
5mM	0.3140 mL	1.5699 mL	3.1398 mL	6.2795 mL
10mM	0.1570 mL	0.7849 mL	1.5699 mL	3.1398 mL
20mM	0.0785 mL	0.3925 mL	0.7849 mL	1.5699 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.