ZM 39923 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1000 | Check With Us |
| 1g | $1650 | Check With Us |
| 5g | $4176 | Check With Us |
: Cat #: V0329 CAS #: 1021868-92-7 Purity ≥ 98%
Description: ZM 39923 HCl, the hydrochloride salt of ZM-39923, is a novel and potent inhibitor of Janus kinase-JAK1/3 with potential anti-inflammatory activity.
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| Molecular Weight (MW) | 367.91 |
|---|---|
| Molecular Formula | C23H25NO.HCl |
| CAS No. | 1021868-92-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 30 mg/mL (81.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 8 mg/mL (21.7 mM) | |
| Synonyms | ZM 39923; ZM-39923; ZM39923 HCl; ZM39923; ZM 39923 Hydrochloride; |
| Protocol | In Vitro | ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7181 mL | 13.5903 mL | 27.1806 mL | 54.3611 mL |
| 5mM | 0.5436 mL | 2.7181 mL | 5.4361 mL | 10.8722 mL |
| 10mM | 0.2718 mL | 1.3590 mL | 2.7181 mL | 5.4361 mL |
| 20mM | 0.1359 mL | 0.6795 mL | 1.3590 mL | 2.7181 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Volume(start)
V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.