ZL0454
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1530 | Check With Us |
| 250mg | $2590 | Check With Us |
| 500mg | $3885 | Check With Us |
: Cat #: V3860 CAS #: 2229042-77-5 Purity ≥ 98%
Description: ZL0454 (ZL-0454), an analog of ZL0420, is a novel potent and highly selective inhibitor of BRD4 (Bromodomain-Containing Protein 4) with nanomolar binding affinities to bromodomains (BDs) of BRD4.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 374.46 |
|---|---|
| Molecular Formula | C18H22N4O3S |
| CAS No. | 2229042-77-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3CCCC3)=O |
| Synonyms | ZL0454; ZL 0454; ZL-0454 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6705 mL | 13.3526 mL | 26.7051 mL | 53.4102 mL |
| 5mM | 0.5341 mL | 2.6705 mL | 5.3410 mL | 10.6820 mL |
| 10mM | 0.2671 mL | 1.3353 mL | 2.6705 mL | 5.3410 mL |
| 20mM | 0.1335 mL | 0.6676 mL | 1.3353 mL | 2.6705 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.