ZK824190
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
: Cat #: V39637 CAS #: 2254001-81-3 Purity ≥ 99%
Description: ZK824190 is an orally available and specific urokinase plasminogen activator (uPA) inhibitor as a highly potential treatment for multiple sclerosis.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 414.40 |
|---|---|
| Molecular Formula | C22H20F2N2O4 |
| CAS No. | 2254001-81-3 |
| SMILES Code | CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O |
| Synonyms | ZK-824859; ZK824859; ZK 824859; |
| Protocol | In Vivo | ZK824190 (2 mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4131 mL | 12.0656 mL | 24.1313 mL | 48.2625 mL |
| 5mM | 0.4826 mL | 2.4131 mL | 4.8263 mL | 9.6525 mL |
| 10mM | 0.2413 mL | 1.2066 mL | 2.4131 mL | 4.8263 mL |
| 20mM | 0.1207 mL | 0.6033 mL | 1.2066 mL | 2.4131 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.