Zinc Pyrithione (OM-1563)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50g	$550	Check With Us
100g	$750	Check With Us
200g	$1125	Check With Us

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Cat #: V1636 CAS #: 13463-41-7 Purity ≥ 98%

Description: Zinc pyrithione (formerly known as OM-1563; AI3-62421; BCJ; BC-J OM1563; Biocut ZP, Finecide ZPT), an ingredient of commercial anti-dandruff shampoos, is an antifungal and antibacterial agent that disrupts membrane transport by blocking the proton pump.

References: Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	317.7
Molecular Formula	C10H8N2O2S2Zn
CAS No.	13463-41-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 30 mg/mL (94.4 mM)r
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	Chemical Name: (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc InChi Key: YZYHTCSREWDSOL-UHFFFAOYSA-O InChi Code: InChI=1S/C5H6NOS.C5H4NOS.Zn/c27-6-4-2-1-3-5(6)8;/h1-5,8H;1-4H;/q2-1;+1/p+1 SMILES Code: C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1
Synonyms	OM-1563; AI3 62421; OM 1563; BC J; AI3-62421; BCJ, AI362421; BC-J OM1563; Biocut ZP, Finecide ZPT, Pyrithione zinc; Zinc pyrithione

Protocol	In Vitro	Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1476 mL	15.7381 mL	31.4762 mL	62.9525 mL
5mM	0.6295 mL	3.1476 mL	6.2952 mL	12.5905 mL
10mM	0.3148 mL	1.5738 mL	3.1476 mL	6.2952 mL
20mM	0.1574 mL	0.7869 mL	1.5738 mL	3.1476 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.