Zidovudine (Azidothymidine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $250 | Check With Us |
| 10g | $450 | Check With Us |
| 20g | $675 | Check With Us |
: Cat #: V1823 CAS #: 30516-87-1 Purity ≥ 98%
Description: Zidovudine (also known as ZDV, Azidothymidine; Retrovir; Zidovudinum, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor (NRTI) which used to treat and prevent HIV.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 267.24 |
|---|---|
| Molecular Formula | C10H13N5O4 |
| CAS No. | 30516-87-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (198.3 mM)r |
| Water: 53 mg/mL (198.3 mM)r | |
| Ethanol: N/A | |
| Solubility In Vivo | 18 mg/mL (67.4 mM) |
| Synonyms | Azidothymidine, NSC-602670, NSC602670, NSC 602670, Zidovudinu; BW A509U; BWA 509U; BWA-509U; BWA509U; ZDV; AZT; Retrovir. |
| Protocol | In Vivo | NRTIs lamivudine (3TC), Zidovudine (AZT), or abacavir (ABC) inhibit laser-induced choroidal neovascularization (CNV) in wild-type mice compared to PBS vectors. The average level of VEGF-A in RPE/choroids peaked on day 3 after laser injury and was significantly reduced in 3TC, AZT, and ABC-treated eyes compared to control eyes in wild-type mice, but in P2rx7-/- Mice |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7420 mL | 18.7098 mL | 37.4195 mL | 74.8391 mL |
| 5mM | 0.7484 mL | 3.7420 mL | 7.4839 mL | 14.9678 mL |
| 10mM | 0.3742 mL | 1.8710 mL | 3.7420 mL | 7.4839 mL |
| 20mM | 0.1871 mL | 0.9355 mL | 1.8710 mL | 3.7420 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.