Zardaverine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $900 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V24190 CAS #: 101975-10-4 Purity ≥ 99%
Description: Zardaverine is a novel and selective PDE (Phosphodiesterase) 3/4 inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively.
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| Molecular Weight (MW) | 268.22 |
|---|---|
| Molecular Formula | C12H10F2N2O3 |
| CAS No. | 101975-10-4 |
| SMILES Code | O=C1C=CC(C2=CC=C(OC(F)F)C(OC)=C2)=NN1 |
| Synonyms | Zardaverine |
| Protocol | In Vitro | Zardaverine (0.01, 0.03, 0.1, 0.3 1 µM/48h; 0.3 1 µM/24, 36, 48, 60, 72 h) induces apoptosis in a time- and concentration- dependent manner, in Bel-7402 and SMMC-7721 cells. Zardaverine (0.1 µM; 24 h) selectively causes G0/G1-phase arrest and dysregulates cell cycle-associated proteins in HCC cells. Zardaverine shows selective antitumor activity that closely related to the regulation of cell cycle-associated proteins, but is independent of PDE3/4 inhibition. Zardaverine (0-30 µM; 72 h) selectively inhibits the growth of human HCC cells in vitro. |
|---|---|---|
| In Vivo | Zardaverine (60, 200 mg/kg; p.o.; single daily for 14 days) inhibits the growth of human Bel-7402 xenografts in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7283 mL | 18.6414 mL | 37.2828 mL | 74.5657 mL |
| 5mM | 0.7457 mL | 3.7283 mL | 7.4566 mL | 14.9131 mL |
| 10mM | 0.3728 mL | 1.8641 mL | 3.7283 mL | 7.4566 mL |
| 20mM | 0.1864 mL | 0.9321 mL | 1.8641 mL | 3.7283 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.