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Zaprinast

This product is for research use only, not for human use. We do not sell to patients.

Zaprinast
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$550Check With Us
250mg$990Check With Us
500mg$1485Check With Us
email: [email protected]        [email protected]

Cat #: V8408 CAS #: 37762-06-4 Purity ≥ 99%

Description: Zaprinast is a potent phosphodiesterase (PDE) inhibitor with selectivity for PDE5, PDE6, PDE9 and PDE11 and IC₅₀ values of 0.76, 0.15, 29.0, and 12.0 μM, respectively.

References: Choi SH , et al. Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. J Neurosci Res. 2002 Feb 1;67(3):411-21.

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Molecular Weight (MW)271.27
Molecular FormulaC13H13N5O2
CAS No.37762-06-4
SMILES CodeO=C1C(NN=N2)=C2NC(C3=CC=CC=C3OCCC)=N1
SynonymsZaprinast
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.6864 mL18.4318 mL36.8636 mL73.7273 mL
5mM0.7373 mL3.6864 mL7.3727 mL14.7455 mL
10mM0.3686 mL1.8432 mL3.6864 mL7.3727 mL
20mM0.1843 mL0.9216 mL1.8432 mL3.6864 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.