Zalcitabine (ddC; Dideoxycytidine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $250 | Check With Us |
| 1g | $400 | Check With Us |
| 5g | $1080 | Check With Us |
: Cat #: V1822 CAS #: 7481-89-2 Purity ≥ 98%
Description: Zalcitabine (trade name Hivid) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 211.22 |
|---|---|
| Molecular Formula | C9H13N3O3 |
| CAS No. | 7481-89-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 42 mg/mL (198.8 mM)r |
| Water: 42 mg/mL (198.8 mM)r | |
| Ethanol: <1 mg/mL | |
| Synonyms | ddC; Dideoxycytidine; 2',3'-Dideoxycytidine; Ro 24-2027/000; Ro-24-2027/000; Ro 24-2027 000; NSC606170; NSC 606170; NSC-606170; Zalcitabine; ddC; dideoxycytidine, Hivid. |
| Protocol | In Vitro | Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.7344 mL | 23.6720 mL | 47.3440 mL | 94.6880 mL |
| 5mM | 0.9469 mL | 4.7344 mL | 9.4688 mL | 18.9376 mL |
| 10mM | 0.4734 mL | 2.3672 mL | 4.7344 mL | 9.4688 mL |
| 20mM | 0.2367 mL | 1.1836 mL | 2.3672 mL | 4.7344 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.