Z-LEHD-FMK
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2950 | To Be Confirmed |
| 250mg | $4300 | To Be Confirmed |
| 500mg | $6450 | To Be Confirmed |
: Cat #: V4117 CAS #: 210345-04-3 Purity ≥ 98%
Description: Z-LEHD-FMK is a cell-permeable, specific, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival and protects against lethal reperfusion injury and attenuates apoptosis.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 690.72 |
|---|---|
| Molecular Formula | C32H43FN6O10 |
| CAS No. | 210345-04-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 10mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2 |
| Synonyms | Z-LEHD-FMK; Z-LEHD-FMK; Z LEHD-FMK; Z LEHD FMK; Z-LEHD FMK |
| Protocol | In Vitro | Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis. Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity. |
|---|---|---|
| In Vivo | Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4478 mL | 7.2388 mL | 14.4776 mL | 28.9553 mL |
| 5mM | 0.2896 mL | 1.4478 mL | 2.8955 mL | 5.7911 mL |
| 10mM | 0.1448 mL | 0.7239 mL | 1.4478 mL | 2.8955 mL |
| 20mM | 0.0724 mL | 0.3619 mL | 0.7239 mL | 1.4478 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.