(Z)-Guggulsterone

This product is for research use only, not for human use. We do not sell to patients.

(Z)-Guggulsterone
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
200mg$1875Check With Us
500mg$3165Check With Us

Cat #: V5032 CAS #: 39025-23-5 Purity ≥ 98%

Description: (Z)-Guggulsterone, the cis-isomer of Guggulsterone, is a naturally occuring phytosteroid isolated from the resin of the guggul plant, Commiphora mukul.

References: Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.

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Product Promise

Promise
Molecular Weight (MW)312.45
Molecular FormulaC21H28O2
CAS No.39025-23-5
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
ProtocolIn Vitro(Z)-Guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC.
In VivoZ-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2005 mL16.0026 mL32.0051 mL64.0102 mL
5mM0.6401 mL3.2005 mL6.4010 mL12.8020 mL
10mM0.3201 mL1.6003 mL3.2005 mL6.4010 mL
20mM0.1600 mL0.8001 mL1.6003 mL3.2005 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.