YM-53601

This product is for research use only, not for human use. We do not sell to patients.

YM-53601
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$290To Be Confirmed
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V8136 CAS #: 182959-33-7 Purity ≥ 99%

Description: YM-53601 is a squalene synthase inhibitor that can reduce plasma cholesterol and triglyceride levels in the body. YM-53601 inhibits squalene synthase developed from human hepatoma cells with IC50 of 79 nM. Can be used as a lipid-lowering agent [2]. YM-53601 is also an inhibitor (blocker/antagonist) of farnesyl diphosphate farnesyl transferase 1 (FDFT1) enzyme activity, which can inhibit HCV (hepatitis C virus) transmission.

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Molecular Weight (MW)372.86
Molecular FormulaC21H22ClFN2O
CAS No.182959-33-7
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.

SynonymsYM-53601 YM53601 YM 53601
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6820 mL13.4099 mL26.8197 mL53.6394 mL
5mM0.5364 mL2.6820 mL5.3639 mL10.7279 mL
10mM0.2682 mL1.3410 mL2.6820 mL5.3639 mL
20mM0.1341 mL0.6705 mL1.3410 mL2.6820 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.