Y06137
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1400 | To Be Confirmed |
| 200mg | $2100 | To Be Confirmed |
| 500mg | $3540 | To Be Confirmed |
: Cat #: V31521 CAS #: 2226534-49-0 Purity ≥ 99%
Description: Y06137 (Y0-6137; Y0 6137)is a novel and potent bromodomain BET inhibitor (Kd = 81 nM.) with potential anticancer activity.
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- Related Biological Data
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| Molecular Weight (MW) | 444.57 |
|---|---|
| Molecular Formula | C27H32N4O2 |
| CAS No. | 2226534-49-0 |
| Synonyms | Y06137; Y0-6137; Y0 6137 |
| Protocol | In Vitro | Y06137 (0.001-100 nM, 96 hours for LNCaP, C4-2B, and 22Rv1 cells; 144 hours for VCaP cells) exhibits low micromolar or nanomolar potencies (IC50: 0.29-2.6 μΜ) in the four androgen receptor (AR)-positive prostate cancer cell lines LNCaP, C4-2B, 22Rv1, and VCaP. Treatment of 22Rv1 cells with Y06137 (1, 2, 4, 8, and 16 μM, 48 hours) results in significant down-regulation of both full-length (AR-fl) and AR variants levels. |
|---|---|---|
| In Vivo | 06137 (50 mg/kg, i.p. injection, 5 times per week, 25 days) demonstrates therapeutic effects in a C4-2B CRPC xenograft tumor model in mice. Y06137 is well tolerated in the treated mice, based on the weight of the animal body and their general behavior. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2494 mL | 11.2468 mL | 22.4936 mL | 44.9873 mL |
| 5mM | 0.4499 mL | 2.2494 mL | 4.4987 mL | 8.9975 mL |
| 10mM | 0.2249 mL | 1.1247 mL | 2.2494 mL | 4.4987 mL |
| 20mM | 0.1125 mL | 0.5623 mL | 1.1247 mL | 2.2494 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.