XL413 (BMS-863233) HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V1543 CAS #: 1169562-71-3 Purity ≥ 98%
Description: XL413 HCl (XL-413; BMS863233; XL 413; BMS-863233), the hydrochloride salt of XL413, is a novel and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antitumor activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 326.18 |
|---|---|
| Molecular Formula | C14H13Cl2N3O2 |
| CAS No. | 1169562-71-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water: 46 mg/mL (141.02 mM)r | |
| Ethanol: <1 mg/mL | |
| Synonyms | XL413; BMS863233; XL-413; BMS-863233; XL 413; BMS 863233. |
| Protocol | In Vitro | XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC50=2685 nM), decreases cell viability (IC50=2142 nM) and elicits the caspase 3/7 activity (EC50=2288 nM) in Colo-205 cells. XL413 hydrochloride also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC50=715 nM) |
|---|---|---|
| In Vivo | XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0658 mL | 15.3290 mL | 30.6579 mL | 61.3158 mL |
| 5mM | 0.6132 mL | 3.0658 mL | 6.1316 mL | 12.2632 mL |
| 10mM | 0.3066 mL | 1.5329 mL | 3.0658 mL | 6.1316 mL |
| 20mM | 0.1533 mL | 0.7664 mL | 1.5329 mL | 3.0658 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.