WHI-P154

This product is for research use only, not for human use. We do not sell to patients.

WHI-P154
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$850Check With Us
500mg$1350Check With Us
1g$2025Check With Us

Cat #: V0340 CAS #: 211555-04-3 Purity ≥ 98%

Description: WHI-P154 is a novel, potent and selective JAK3 (Janus kinase) inhibitor with potential antitumor activity.

References: Changelian PS, et al. The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. Epub 2007 Dec 19.

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Product Promise

Promise
Molecular Weight (MW)376.2
Molecular FormulaC16H14BrN3O3
CAS No.211555-04-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 71 mg/mL (199.3 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
Solubility In Vivo30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SMILES CodeOC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br
SynonymsJanex1; WHIP-154; WHI P154; WHIP154
ProtocolIn Vivoreache a size > 50 mm3.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6582 mL13.2908 mL26.5816 mL53.1632 mL
5mM0.5316 mL2.6582 mL5.3163 mL10.6326 mL
10mM0.2658 mL1.3291 mL2.6582 mL5.3163 mL
20mM0.1329 mL0.6645 mL1.3291 mL2.6582 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.