VUF10460
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $745 | Check With Us |
| 500mg | $1345 | Check With Us |
| 1g | $2015 | Check With Us |
: Cat #: V3236 CAS #: 1028327-66-3 Purity ≥ 98%
Description: VUF10460 is a non-imidazole agonist of the histamine H4 receptor which binds to rat H4 receptor with a pKi of 7.46.
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| Molecular Weight (MW) | 269.34 |
|---|---|
| Molecular Formula | C₁₅H₁₉N₅ |
| CAS No. | 1028327-66-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 30 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1 |
| Synonyms | VUF10460; VUF-10460; VUF 10460 |
| Protocol | In Vitro | UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor |
|---|---|---|
| In Vivo | HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7128 mL | 18.5639 mL | 37.1278 mL | 74.2556 mL |
| 5mM | 0.7426 mL | 3.7128 mL | 7.4256 mL | 14.8511 mL |
| 10mM | 0.3713 mL | 1.8564 mL | 3.7128 mL | 7.4256 mL |
| 20mM | 0.1856 mL | 0.9282 mL | 1.8564 mL | 3.7128 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.