VU6015929
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2450 | Check With Us |
| 1g | $3675 | Check With Us |
: Cat #: V34659 CAS #: N/A Purity ≥ 99%
Description: VU6015929 is a selective and orally bioavailable dual inhibitor of discoidin domain receptor 1/2 (DDR1/2) with IC50s of 4.67 nM and 7.39 nM, respectively.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 485.43 |
|---|---|
| Molecular Formula | C24H19F4N5O2 |
| CAS No. | N/A |
| SMILES Code | FC1=CC=C(C(NC2=CC=CC(OC(F)(F)F)=C2)=O)C=C1NCC3=CC(C4=NN(C)C=C4)=CN=C3 |
| Synonyms | VU6015929; VU 6015929; VU-6015929 |
| Protocol | In Vitro | VU6015929 (Compound 7e; 4-100 nM; 24 hours; HEK293-DDR1b cells) treatment inhibits collagen I-induced DDR1 phosphorylation in a dose dependent manner. Analysis of the phosphorylated DDR1/total DDR1 ratio reveals an IC50 for VU6015929 of 0.7078 nM. |
|---|---|---|
| In Vivo | VU6015929 (Compound 7e) is further evaluated in a rat IV (0.5 mg/kg)/PO (3 mg/kg) PK study in a 10% EtOH/40% PEG400/50% saline vehicle. VU6015929 displays a good in vitro:in vivo correlation (IVIC), with moderate in vivo clearance (CLp = 34.2 mL/min/kg), an ~3 hour half-life, moderate volume of distribution at steady state (Vss = 4.3 L/kg) and 12.5% oral bioavailability with a rapid Tmax (0.75 hr). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0600 mL | 10.3001 mL | 20.6003 mL | 41.2006 mL |
| 5mM | 0.4120 mL | 2.0600 mL | 4.1201 mL | 8.2401 mL |
| 10mM | 0.2060 mL | 1.0300 mL | 2.0600 mL | 4.1201 mL |
| 20mM | 0.1030 mL | 0.5150 mL | 1.0300 mL | 2.0600 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.