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| Size | Price | Stock |
|---|---|---|
| 1mg | $90 | In Stock |
| 5mg | $140 | In Stock |
| 10mg | $250 | In Stock |
| 25mg | $410 | In Stock |
| 50mg | $610 | In Stock |
| 100mg | $860 | In Stock |
: Cat #: V41516 CAS #: 2290608-13-6 Purity ≥ 99%
Description: VT-103 (VT103) is an oral and potent TEAD1 protein Auto-palmitoylation inhibitor with anticancer activity. It inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD.VT-103 exhibited excellent oral bioavailability and pharmacokinetics with the ability to selectively inhibit NF2-deficient mesothelioma cell proliferation in vitro and growth of subcutaneous tumor xenografts in vivo. These highly potent and selective TEAD inhibitors provide a way to target the Hippo-YAP pathway, which thus far has been undruggable and is dysregulated frequently in malignant mesothelioma and in other YAP-driven cancers and diseases.
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| Molecular Weight (MW) | 410.413392782211 |
|---|---|
| Molecular Formula | C18H17F3N4O2S |
| CAS No. | 2290608-13-6 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | VT-103; VT 103; VT103 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4366 mL | 12.1828 mL | 24.3657 mL | 48.7314 mL |
| 5mM | 0.4873 mL | 2.4366 mL | 4.8731 mL | 9.7463 mL |
| 10mM | 0.2437 mL | 1.2183 mL | 2.4366 mL | 4.8731 mL |
| 20mM | 0.1218 mL | 0.6091 mL | 1.2183 mL | 2.4366 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.