Vorinostat (SAHA; MK0683)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $600 | In Stock |
| 25g | $1050 | In Stock |
| 50g | $1575 | In Stock |
: Cat #: V0255 CAS #: 149647-78-9 Purity ≥ 98%
Description: Vorinostat (formerly known as suberanilohydroxamic acid, MK-0683; CCRIS-8456; HSDB 7930; SAHA; trade name: Zolinza) is a potent, orally bioavailable and non-selective pan-inhibitor of histone deacetylases (HDACs) with antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 264.3 |
|---|---|
| Molecular Formula | C14H20N2O3 |
| CAS No. | 149647-78-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (200.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 3 mg/mL (11.4 mM) | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+ddH2O: 5 mg/mL |
| Synonyms | MK0683; SAHA; M344; CCRIS 8456; CCRIS8456; CCRIS-8456; HSDB 7930; Vorinostat; suberoylanilide hydroxamic acid; MK-0683, MK 0683, MK0683, M344, HSDB 7930; Trade name: Zolinza |
| Protocol | In Vitro | Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21WAF1 expression and apoptosis in MES-SA cells |
|---|---|---|
| In Vivo | Vorinostat (50 mg/kg/day) reduces tumor growth by more than 50% in nude mice injected with 5×106 MES-SA cells |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7836 mL | 18.9179 mL | 37.8358 mL | 75.6716 mL |
| 5mM | 0.7567 mL | 3.7836 mL | 7.5672 mL | 15.1343 mL |
| 10mM | 0.3784 mL | 1.8918 mL | 3.7836 mL | 7.5672 mL |
| 20mM | 0.1892 mL | 0.9459 mL | 1.8918 mL | 3.7836 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.