Volasertib (BI 6727)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2975 | Check With Us |
: Cat #: V1574 CAS #: 755038-65-4 Purity ≥ 98%
Description: Volasertib (formerly also known as BI6727, BI-6727, BI 6727) is a novel and highly potent dihydropteridinone-based Plk1 (polo-like kinase 1) inhibitor with potential antineoplastic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 618.81 |
|---|---|
| Molecular Formula | C34H50N8O3 |
| CAS No. | 755038-65-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 20 mg/mL (32.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 4% DMSO+Corn oil: 2 mg/mL |
| Synonyms | BI6727, BI-6727, BI 6727; N-((1s,4S)-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxybenzamide |
| Protocol | In Vitro | Volasertib (BI 6727；0.01-10000 nM； 72 hours) in a variety of cell lines[1]EC in 50 Values range from 11 to 37 nmol/L. Volasertib (10-1000 nM； 24 hours) causes cells to accumulate 4N DNA content, indicating cell cycle arrest in the G2-M phase |
|---|---|---|
| In Vivo | Volasertib (BI 6727; total weekly dose 50 mg/kg; Take orally; Once a week, twice a week, or once a day; for 40 days) has shown considerable efficacy in human colon cancer xenograft models | |
| Animal model | Female BomTac:NMRI-Foxn1Right away mice (Taconic) were grafted s.c. with HCT 116 human colon carcinoma cells (ATCC CCL-247) | |
| Dosages | A total weekly dose of 50 mg/kg | |
| Administration | Oral; once a week, twice a week, or daily; for 40 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6160 mL | 8.0800 mL | 16.1600 mL | 32.3201 mL |
| 5mM | 0.3232 mL | 1.6160 mL | 3.2320 mL | 6.4640 mL |
| 10mM | 0.1616 mL | 0.8080 mL | 1.6160 mL | 3.2320 mL |
| 20mM | 0.0808 mL | 0.4040 mL | 0.8080 mL | 1.6160 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.